URINE DRUG ANALYSIS | Iowa Department of Public Safety

Drug analysis samples can be submitted in the gray stoppered tubes used for alcohol analysis, and/or bottles, containers, or equivalent.

The detection of drugs in a urine sample is determined by initial screening or presumptive tests. These tests target compounds in a drug group rather than specific drugs. Following a positive screening result on a sample, a second confirmatory test is performed. This second test uses a different analytical technique to identify a specific drug compound.

Randox Screening Drugs and Levels:

The “Screening of Drugs” lists the drug categories for DOA1+ and DOAV screening panels. DOA1+ testing is performed on all urine samples requesting drug screen analysis (pre-log: TXUD). Depending on specific agency requests, DOAV testing may be completed. DOA1+ and DOAV panels are completed using a Randox Instrument.


Randox Screening Levels - DOA ULTRA Urine
Drug Group:	2023	2022
Oxycodone 1 (OXYC 1) (Oxy's)	≥223	≥50
Oxycodone 2 (OXYC 2) (Oxy's)	≥223	≥50
Generic Opioids (OPDS) (Hydro's)	≥375	≥50
Opiates (OPIAT) (morphine/codeine)	≥2632	≥2597
Dextromethorphan (DMP)	≥25	≥25
Meprobamate (MPB)	≥250	≥250
Amphetamine (AMPH)	≥625	≥595
Methamphetamine (MAMP)	≥582	≥588
Barbiturates (BARB)	≥200	≥200
Benzodiazepine 1 (BENZ 1)	≥50	≥50
Benzodiazepine 2 (BENZ 2)	≥50	≥50
Methadone (MDONE)	≥150	≥150
Phencyclidine (PCP)	≥33	≥32
Benzoylecgonine (BZG)	≥175	≥187
Zolpedim (ZOL)	≥10	≥10
Tricyclic Antidepressants (TCA)	≥100	≥100
Cannabinoids (THC)	≥63	≥67
Tramadol (TRM)	≥10	≥10
Fentanyl (FENT)	≥2	≥2
Buprenorphine (BUP)	≥5	≥5

Confirmation of Drug Categories (Confirmations):

When a screening test is positive, a confirmatory test is performed to identify the drug. “Confirmation of Drug Categories” lists drug compounds that are typically reported following this second, confirmatory test.


Confirmation of Drug Categories (Confirmations)
Amphetamines Confirmation (Urine Samples):
amphetamine methamphetamine 3,4-methylenedioxyamphetamine (MDA) 3,4-methylenedioxymethamphetamine (MDMA) Phentermine
Barbituates Confirmation (Urine Samples):
butalbital secobarbital butabarbital amobarbital hexobarbital phenobarbital
Opiates Confirmation (Urine Samples):
6-MAM buprenorphine codeine dihydrocodeine fentanyl hydrocodone hydromorphone meperidine methadone morphine norbuprenorphine norcodeine norfentanyl normorphine oxycodone oxymorphone propoxyphene

Cannabinoids Confirmation (Urine Samples):	Common Name:
11-nor-9-carbody-delta-9-tetrahydrocannabinol	metabolite of THC
Cocaine Confirmation (Urine Samples):	Common Name:
benzolyecgonine	metabolite of cocaine
cocaine	---
ecgonine methyl ester	metabolite of cocaine
ethylbenzoylecgonine	Cocaethylene, a metabolite of cocaine
Benzodiazepines and Sleep Drugs (Urine Samples):	Common Name:
7-aminoclonazepam	metabolite of clonazepam
7-aminoflurazepam	metabolite of flurazepam
alphahydroxyalprazolam	alprazolam metabolite
alphahydroxymidazolam	metabolite of midazolam
alphahydroxytriazolam	metabolite of triazolam
alprazolam	Xanax
bromazepam
chlordiazepoxide	librium
clonazepam	Klonopin
desalkyflurazepam	metabolite of flurazepam
diazepam	Valium
estazolam
flunitrazepam	rohypnol
flurazepam	dalmane
halazepam
hydroxyethylflurazepam	metabolite of flurazepam
lorazepam	Activan
midazolam	versed
nordiazepam	metabolite of diazepam, chloradiazepoxide and halazepam
oxazepam	also a metabolite of temazepam and diazepam
temazepam	also a metabolite of diazepam
traizolam	halcion
zolpiclone	lunesta
zopidem	ambien

Target Compounds:

“Target compounds” provides a list of drugs for a special type of screening method employing an instrument called the LCMSMS. Rather than drug categories, it focuses on drug compounds. This screening test is used in cases of Drug Facilitated Sexual Assault and other toxicology cases with special drug requests and cases that require additional information for confirmation testing.

Target Drugs Tested for in Toxicology (Urine Samples): Last Updated: February 2017
1	2CB	70	Ethenzamide	139	Nitrazepam
2	2-oro-3-hydroxy LSD	71	Fenspiride	140	Norbuprenorphine
3	4-MePPP	72	Fentanyl	141	Norclomipramine
4	4-chloro-2,5-dimethoxyamphetamine (DOC)	73	Flecainide	142	Nordiazepam
5	5-methoxy-DALT	74	Flumazenil	143	Nordoxepin
6	6MAM	75	Flunitrazepam	144	Norfentanyl
7	7-aminoclonazepam	76	Fluoxetine	145	Norfluoxetine
8	7-aminoflunitrazepam	77	Fluphenazine	146	Norketamine
9	7-hydroxyquetiapine	78	Flurazepam	147	Normeperidine
10	4-fluormethamphetamine	79	Fluvoxamine	148	Norpropoxyphene
11	Acebutolol	80	Gabapentin	149	Norquetiapine
12	Acetylfentanyl	81	Haloperidol	150	Nortriptyline
13	alpha-PVP	82	Heroin	151	Norverapamil
14	Alprazolam	83	Hydrocodone	152	O-desmethylvenlafaxine
15	Amiodarone	84	Hydromorphone	153	Olanzapine
16	Amitriptylene	85	Hydroquinidine	154	Orphenadrine
17	Amoxapine	86	Hydroxyalprazolam	155	Oxazepam
18	Amphetamine	87	Hydroxyzine	156	Oxcarbazepine
19	Atenolol	88	Imipramine	157	Oxprenolol
20	Atropine	89	Indomethazin	158	Oxycodone
21	Benzoylecgonine	90	Isometheptene	159	Paracetamol
22	Benzylpiperazine	91	25-I-NBoMe	160	Paroxetine
23	Betaxolol	92	Ketamine	161	PCP
24	Bisoprolol	93	Labetolol	162	Pentadrone
25	Bromazepam	94	Lamotrigine	163	Perphenazine
26	Brompheniramine	95	Lidocaine	164	Pheniramine
27	Bupivacaine	96	Loprazolam	165	Phenothiazine(2)
28	Buprenorphine	97	Lorazepam	166	Phenotiazine (1)
29	Bupropion	98	Lormetazepam	167	Phenylpropanolamine (PPA)
30	Bupropion hydroxyl metabolite	99	Loxapine	168	Phenytoin
31	Butorphanol	100	LSD	169	Pindolol
32	Caffeine	101	Maprotiline	170	Piroxicam
33	Carbamazepine	102	MBDB	171	Prazepam
34	Carbamazepine 10,11 epoxide	103	mCPP	172	Primidone
35	Carisoprodol	104	MDA	173	Procaine
36	Cathine	105	MDEA	174	Promethazine
37	Cathinone	106	MDMA	175	Propafenone
38	Chlordiazepoxide	107	MDPV	176	Propanolol
39	Chloroquine	108	Meloxicam	177	Propoxyphene
40	Chlorpheniramine	109	Meperidine	178	Pseudoephedrine
41	Chlorpromazine	110	Mephedrone	179	Quetiapine
42	Citalopram	111	Meprobamate	180	Quinidine
43	Clenbuterol	112	Mescaline	181	Reserpine
44	Clobazam	113	Methadone	182	Risperidone
45	Clomipramine	114	Methamphetamine	183	Salbutamol
46	Clonazepam	115	Methaqualone	184	Scopolamine
47	Clonidine	116	Methedrone	185	Sertraline
48	Clozapine	117	Methocarbamol	186	Strychnine
49	Cocaine	118	Methyl Clonazepam	187	Sundilac
50	Codeine	119	Methylhexanamine	188	Tapentaldol
51	Colchicine	120	Methylphenidate	189	Temazepam
52	Cyclobenzaprine	121	Metoclopramide	190	Tetracaine
53	Desalkyl flurazepam	122	Metoprolol	191	Tetrazepam
54	Desipramine	123	Mianserine	192	TFMPP
55	Desmethylcyclobenzaprine	124	Midazolam	193	Theophylline
56	Dextromethorphan	125	Milnacipran	194	Thioridazine
57	Dextrorphan	126	Mitragynine	195	Tiapride
58	Diazepam	127	Mirtazepine	196	Topiramate
59	Dihydrocodeine	128	Modafinil	197	Tramadol
60	Diltiazem	129	Molsidomine	198	Trazodone
61	Diphenhydramine	130	Morphine	199	Triazolam
62	Disopyramide	131	Nadolol	200	Trifluoperazine
63	Doxepin	132	Nalbuphine	201	Trimipramine
64	Doxylamine	133	Nalorphine	202	Tripolidine
65	Droperidol	134	Naltrexone	203	Venlafaxine
66	Duloxetine	135	Naphazoline	204	Verapamil
67	EDDP	136	Naproxen	205	Zolpidem
68	Ephedrine	137	n-desmethyltramadol	206	Zopiclone
69	Estazolam	138	Nicotine